期刊
MICROBIAL PATHOGENESIS
卷 78, 期 -, 页码 1-6出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.micpath.2014.11.003
关键词
HIV-1 brain; HIV-1 persistence; Lysosomotropic drugs; Chloroquine; Proteasome inhibitors; LSP1; Rab; Rev; Tat
资金
- NIH [RO1 NS0064]
- University of South Carolina School of Medicine
Despite successful suppression of peripheral HIV-1 infection by combination antiretroviral therapy, immune activation by residual virus in the brain leads to HIV-associated neurocognitive disorders (HAND). In the brain, several types of cells, including microglia, perivascular macrophage, and astrocytes have been reported to be infected by HIV-1. Astrocytes, the most abundant cells in the brain, maintain homeostasis. The general consensus on HIV-1 infection in astrocytes is that it produces unproductive viral infection. HIV-1 enters astrocytes by pH-dependent endocytosis, leading to degradation of the virus in endosomes, but barely succeeds in infection. Here, we have discussed endocytosis-mediated HIV-1 entry and viral programming in astrocytes. (C) 2014 Elsevier Ltd. All rights reserved.
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