期刊
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
卷 28, 期 5, 页码 441-449出版社
WILEY
DOI: 10.1002/gps.3845
关键词
depression; dementia; mild cognitive impairment; meta-analysis
资金
- Key Projects of Medical Science
- Chongqing Municipal Health Bureau in China [2010-1-8]
- Natural Science Foundation of Chongqing in China (CSTC) [2010BB5396]
- National Foundation of Natural Science of China [81170752]
Background This study examined whether depression was a risk factor for onset of dementia including Alzheimer's disease (AD), vascular dementia (VD) and any dementia, and mild cognitive impairment (MCI) by using a quantitative meta-analysis of longitudinal studies. Methods EMBASE and MEDLINE were searched for articles published up to February 2011. All studies that examined the relationship between depression and the onset of dementia or MCI were included. Pooled relative risk was calculated using fixed-effects models. Results Twelve studies met our inclusion criteria for this meta-analysis. All subjects were without dementia or MCI at baseline. Four, two, five, and four studies compared the incidence of AD, VD, any dementia, and MCI between subjects with or without depression, respectively. After pooling all the studies, subjects with depression had higher incidence of AD (relative risk (RR):1.66, 95% confidence interval (CI): 1.292.14), VD (RR: 1.89, 95% CI: 1.193.01), any dementia (RR: 1.55, 95% CI: 1.312.83), and MCI (RR: 1.97, 95% CI: 1.532.54) than those without depression. Conclusions The quantitative meta-analysis showed that depression was a major risk factor for incidence of dementia (including AD, VD, and any dementia) and MCI. Copyright (c) 2012 John Wiley & Sons, Ltd.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据