期刊
MICROBES AND INFECTION
卷 17, 期 2, 页码 163-168出版社
ELSEVIER
DOI: 10.1016/j.micinf.2014.12.003
关键词
West Nile virus; Persistence; Renal outcomes; Neurologic outcomes; Morbidity; Mortality
资金
- NIH/NIAID [1R01AI091816-01]
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI091816] Funding Source: NIH RePORTER
West Nile virus (WNV) is a widespread global pathogen that results in significant morbidity and mortality. Data from animal models provide evidence of persistent renal and neurological infection from WNV; however, the possibility of persistent infection in humans and long-term neurological and renal outcomes related to viral persistence remain largely unknown. In this paper, we provide a review of the literature related to persistent infection in parallel with the findings from cohorts of patients with a history of WNV infection. The next steps for enhancing our understanding of WNV as a persistent pathogen are discussed. (C) 2014 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.
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