期刊
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
卷 24, 期 2, 页码 109-117出版社
WILEY
DOI: 10.1002/gps.2087
关键词
aging; white matter; MRI
资金
- National Institute of Mental Health [K23 MH074818, R01 MH65653, P30 MH68638]
- National Institute on Aging [K23 AG029949]
- Atzheirner's Assoeiation [NIRG-05-14586]
Background Cerebral aging is a complex and heterogeneous process that is associated with a high degree of inter-individual variability. Structural magnetic resonance imaging (MRI) can be used to identify and quantify non-disease-related aging of the cerebral white matter. Methods The present article reviews the findings from several MRI techniques, including morphometric approaches, study of white matter hyperintensities, diffusion tensor imaging, and magnetization transfer imaging, that have been used to examine aging of the cerebral while matter. Furthermore, the relationship of MRI indices of white matter integrity to agerelated cognitive declines is reported. Results; A general pattern of age-related preservation and decline emerges indicating that the prefrontal white matter is most susceptible to the influence of age. Studies that combine MRI with cognitive measures suggest that such age-related reductions in white matter integrity may produce a disconnection state that underlies some of the age-related performance declines in age-sensitive cognitive domains. Conclusions White matter aging may contribute to a disconnection state that is associated with declines in episodic memory, executive functions, and information processing speed. Copyright (C) 2008 John Wiley & Sons, Ltd.
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