期刊
INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION
卷 65, 期 1, 页码 97-100出版社
TAYLOR & FRANCIS LTD
DOI: 10.3109/09637486.2013.832172
关键词
Obesity; pancreatic lipase; stilbenenoids; Vitis vinifera; wilsonol C
资金
- Basic Science Research Program of the National Research Foundation of Korea (NRF)
- Ministry of Education, Science and Technology [2010-0022783]
- National Research Foundation of Korea [2010-0022783] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Bioassay-guided isolation of an aqueous methanolic extract of Vitis vinifera using pancreatic lipase inhibitory activity led to isolation of seven stilbenoids, wilsonol C (1), heyneanol A (2), ampelopsin A (3), pallidol A (4), cis-piceid (5), trans-piceid (6) and trans-resveratrol (7). The structures were established on the basis of NMR and MS spectroscopic data interpretation. All isolates were evaluated for their inhibitory effects on pancreatic lipase, and stilbenoid 1 exhibited potent inhibitory effect on pancreatic lipase with IC50 values of 6.7 +/- 0.7 mu M.
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