期刊
METHODS
卷 72, 期 -, 页码 3-8出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ymeth.2014.08.011
关键词
HumanMethylation450; Epigenetics; Analysis pipelines; EWAS; DNA methylation; 450k BeadChip
资金
- Wellcome Trust [99148]
- Royal Society Wolfson Research Merit Award [WM100023]
- EU-FP7 project IDEAL [259679]
- EU-FP7 project EPIGENESYS [257082]
- EU-FP7 project BLUEPRINT [282510]
The Illumina HumanMethylation450 BeadChip has become a popular platform for interrogating DNA methylation in epigenome-wide association studies (EWAS) and related projects as well as resource efforts such as the International Cancer Genome Consortium (ICGC) and the International Human Epigenome Consortium (IHEC). This has resulted in an exponential increase of 450k data in recent years and triggered the development of numerous integrated analysis pipelines and stand-alone packages. This review will introduce and discuss the currently most popular pipelines and packages and is particularly aimed at new 450k users. (C) 2014 The Authors. Published by Elsevier Inc.
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