期刊
METHODS
卷 72, 期 -, 页码 65-75出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ymeth.2014.10.031
关键词
Chromosome conformation capture; Deep sequencing; Chromatin structure; Bioinformatics; Hi-C
资金
- National Human Genome Research Institute [HG003143, HG007010]
- Human Frontier Science Program [LT000706/2012]
Over the last decade, development and application of a set of molecular genomic approaches based on the chromosome conformation capture method (3C), combined with increasingly powerful imaging approaches, have enabled high resolution and genome-wide analysis of the spatial organization of chromosomes. The aim of this paper is to provide guidelines for analyzing and interpreting data obtained with genome-wide 3C methods such as Hi-C and 3C-seq that rely on deep sequencing to detect and quantify pairwise chromatin interactions. (C) 2014 Elsevier Inc. All rights reserved.
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