期刊
METHODS
卷 72, 期 -, 页码 57-64出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ymeth.2014.10.033
关键词
Histones; Chromatin; Epigenetics; Proteomics; Mass spectrometry; SILAC
资金
- Thought Leader Award
- Agilent Technologies Foundation
- Agilent Technologies, Inc.
- [R21 DA025720-02]
- [U01 CA164186-02]
Epigenetic control of genome function is an important regulatory mechanism in diverse processes such as lineage commitment and environmental sensing, and in disease etiologies ranging from neuropsychiatric disorders to cancer. Here we report a robust, high-throughput targeted, quantitative mass spectrometry (MS) method to rapidly profile modifications of the core histones of chromatin that compose the epigenetic landscape, enabling comparisons among cells with differing genetic backgrounds, genomic perturbations, and drug treatments. (C) 2014 ElsevierInc. All rights reserved.
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