期刊
INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY
卷 137, 期 2-3, 页码 186-189出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijfoodmicro.2009.10.033
关键词
High-pressure processing; Murine norovirus-1; Mechanism; Capsid protein
资金
- National High-tech Research and Development Project of China [2006AA09Z444]
- Specialized Research Fund for the Doctoral Program of Higher Education [200804231017]
Murine norovirus-1 (MNV) is currently the most suitable surrogate for human norovirus. The mechanism of MNV-1 inactivation by high pressure processing (HPP) was investigated. HPP-treated MNV could not bind to its target receptor and therefore could not initiate infection of mouse RAW cells. The integrity of the capsid was not affect by HPP. Partial motif changes of the viral capsid caused by HPP were accessed by induced sensitivity to proteinase K. (C) 2009 Elsevier B.V. All rights reserved.
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