期刊
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
卷 42, 期 2, 页码 506-517出版社
OXFORD UNIV PRESS
DOI: 10.1093/ije/dyt002
关键词
Body weight; overweight; obesity; child development; cognition; psychomotor performance
资金
- Spanish Ministry of Health-Instituto de Salud Carlos III [Red INMA G03/176, CB06/02/0041, FIS-PI041436, FIS-PI081151, FIS-PI042018, FISPI09/02311, FIS-PI06/0867, FIS-PS09/00090, FIS-FEDER 03/1615, 04/1509, 04/1112, 04/1931, 05/1079, 05/1052, 06/1213, 07/0314, 09/02647]
- Generalitat de Catalunya [CIRIT 1999SGR 00241]
- Conselleria de Sanitat Generalitat Valenciana
- Universidad de Oviedo
- Obra social Cajastur
- Department of Health of the Basque Government [2005111093, 2009111069]
- Provincial Government of Gipuzkoa [DFG06/004, DFG08/001]
- Fundacion Roger Torne (INMA Project)
- European project : EU [FP7-2008-ENV-1.2.1.4]
- Greek Ministry of Health
- European project: EU [FP6-2003-Food-3-A NewGeneris, FP6. STREP Hiwate, FP7 ENV. 2007.1.2.2.2]
- EU [FP7-HEALTH-2009, 241604 CHICOS, FP7-ENV-2008, 226285 ENRIECO]
- [211250 Escape]
Background Maternal pre-pregnancy obesity may be associated with impaired infant neuropsychological development; however, there are few studies and it is unclear if reported associations are due to intrauterine mechanisms. Methods We assessed whether maternal pre-pregnancy overweight and obesity were associated with cognitive and psychomotor development scores (mean 100 +/- 15) of children aged 11-22 months in two birth cohorts: Environment and Childhood (INMA, Spain; n = 1967) and Mother-Child (RHEA, Greece: n = 412). Paternal body mass index (BMI) was used as a negative control exposure. Results The percentage of overweight and obese mothers was 18% and 8%, respectively, in INMA and 20% and 11% in RHEA, respectively. Maternal pre-pregnancy obesity was associated with reduced infant cognitive development scores in both INMA (score reduction: -2.72; 95% CI: -5.35, -0.10) and RHEA (score reduction: -3.71; 95% CI: -8.45, 1.02), after adjusting for socioeconomic variables and paternal BMI. There was evidence in both cohorts of a dose-response relationship with continuous maternal BMI. Paternal overweight/obesity was not associated with infant cognitive development. Associations with psychomotor scores were not consistent between cohorts, and were stronger for paternal than maternal BMI in RHEA. Conclusions This study in two birth cohorts with moderately high obesity prevalence suggests that maternal pre-pregnancy obesity is associated with reduced child cognitive development at early ages. This association appears more likely to be due to maternal than shared family and social mechanisms, but further research is needed to disentangle a direct intrauterine effect from other maternal confounding factors.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据