期刊
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
卷 38, 期 4, 页码 1008-1016出版社
OXFORD UNIV PRESS
DOI: 10.1093/ije/dyp148
关键词
HIV seroprevalence; geographical information systems; disease clustering; small-area variation
资金
- National Institute of Child Health and Human Development [1R01-HD058482-01]
- Africa Centre's Demographic Surveillance Information System
- Wellcome Trust, UK [GR065377/Z/01/B]
Methods All 12 221 participants who consented to an HIV test in a population under continuous demographical surveillance were linked to their homesteads and geo-located in a geographical information system (accuracy of 2 m). We then used a two-dimensional Gaussian kernel of radius 3 km to produce robust estimates of HIV prevalence that vary across continuous geographical space. We also applied a Kulldorff spatial scan statistic (Bernoulli model) to formally identify clusters of infections (P 0.05). Results The results reveal considerable geographical variation in local HIV prevalence (range 636) within this relatively homogenous population and provide clear empirical evidence for the localized clustering of HIV infections. Three high-risk, overlapping spatial clusters [Relative Risk (RR) 1.341.62] were identified by the Kulldorff statistic along the National Road (P 0.01), whereas three low risk clusters (RR 0.20.38) were identified elsewhere in the study area (P 0.017). Conclusions The findings show the existence of several localized HIV epidemics of varying intensity that are partly contained within geographically defined communities. Despite the overall high prevalence of HIV in many rural South African settings, the results support the need for interventions that target socio-geographic spaces (communities) at greatest risk to supplement measures aimed at the general population.
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