期刊
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
卷 39, 期 2, 页码 530-538出版社
OXFORD UNIV PRESS
DOI: 10.1093/ije/dyp354
关键词
Coronary; disease; estrogens; hydrocortisone; mortality; neoplasms; prospective studies; psychological stress
资金
- Danish Research Counsel [271-06-0687]
- Danish Cancer Society
- Lundbeck Foundation
- Danish Heart Association
Methods Estradiol and cortisol were measured in a subset of 838 women randomly drawn from the second wave of the Copenhagen City Heart Study (n = 5297 examined in 1981-83) as well as among all women who developed hormone-dependent cancers after baseline. The participants were followed in nationwide registers until 2007, with < 0.1% loss to follow-up. Results The C/E ratio was not associated with self-reported stress, and there were no clear associations with IHD (highest vs lowest quartile: HR = 1.23; 95% confidence interval 0.83-1.81), hormone-dependent cancers (0.69; 0.45-1.08) or all-cause mortality (1.10; 0.86-1.41). Conclusions The C/E ratio was not associated with morbidity and mortality in women, and we cannot replicate the robust findings of a relation between the cortisol to testosterone ratio and IHD previously reported in men. Whether the C/E ratio is a reasonable biomarker of stress is debatable.
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