期刊
METALLOMICS
卷 7, 期 6, 页码 979-985出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4mt00331d
关键词
-
资金
- Sir Henry Dale Fellowship - Wellcome Trust
- Royal Society [102549/Z/13/Z]
The mammalian immune system has evolved sophisticated mechanisms to withhold essential micronutrients from invading pathogens. These processes, collectively known as nutritional immunity serve to limit microbial proliferation and bolster killing of the invader. Successful pathogens, therefore, have developed strategies to counteract nutritional immunity and acquire essential micronutrients in the restrictive environment of the infected host. Here I take advantage of the now large number of sequenced fungal genomes to explore the zinc acquisition strategies of human fungal pathogens and reflect on the evolutionary context of these uptake pathways.
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