Aripiprazole in Anorexia Nervosa and Low-Weight Bulimia Nervosa: Case Reports

Objective: There has been much interest in the use of atypical antipsychotics in anorexia nervosa (AN). However, newer, more weight-neutral medications have not been studied in AN, and there are no reports of the use of antipsychotics in bulimia nervosa (BN). Method: We report on the treatment of eight patients (five with AN and three with BN) with aripiprazole for time periods of four months to more than three years. Results: All individuals had reduced distress around eating, fewer obsessional thoughts about food, weight and body image, significant lessening of eating-disordered behaviors, and gradual weight restoration where appropriate. Depression, generalized anxiety, and cognitive flexibility improved as well. Discussion: In summary, these findings support the need to perform controlled trials of aripiprazole in AN and BN. (C) 2010 by Wiley Periodicals, Inc.