期刊
METALLOMICS
卷 7, 期 11, 页码 1508-1514出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5mt00188a
关键词
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资金
- National Natural Science Foundation of China [11375213, 21390411]
- National Basic Research Program of China [2011CB933101]
- Hundred Talents Program of the Chinese Academy of Sciences
- IHEP Innovation Program
Small-molecule ligands for stabilizing the G-quadruplex in telomeres are promising chemotherapeutic agents. Despite extensive research, few G-quadruplex-stabilizing ligands have been clinically approved to date. We hypothesized that metal ions may be able to interfere with the ligand-mediated stabilization of the G-quadruplex. Here we found that several metal ions could interfere with the Na+-induced G-quadruplex conformation even in the presence of a ligand. The destabilizing effects of metal ions may not be negligible as most of them are essential elements in organisms. In contrast, Ba2+ was found to be a potent stabilizing cation, which could compete with other destabilizing cations to modulate the stability of the G-quadruplex. Moreover, the destabilizing effects of divalent or trivalent cations were considerably inhibited when a metal chelator was used. These data suggested that the unfavorable effects of destabilizing cations must be minimized for enhancing the ligand-mediated stabilization of the G-quadruplex.
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