期刊
INTERNATIONAL JOURNAL OF DIABETES IN DEVELOPING COUNTRIES
卷 28, 期 3, 页码 83-85出版社
SPRINGER INDIA
DOI: 10.4103/0973-3930.44078
关键词
Alloxan diabetes; brain-dysfunction; glucose metabolism; proteins; proteolysis
Background and Aim: Diabetes mellitus is known to cause neurological disorders due to impaired glucose metabolism involving decreased utilization of glucose by the brain tissues. The mechanisms responsible for failure of glycemic regulation in type-2 diabetes leading to neurological impairment need to be thoroughly elucidated. Materials and Methods : Type-2 diabetes was induced in albino rat models with alloxan monohydrate (40 mg/kg i.v.). Cerebral cortex and medulla oblongata were investigated 48 h after alloxan administration for the alterations in proteolytic activity. Results : Diabetes caused an elevation ( P < 0.001) of blood glucose and also proteolytic activity in the brain. Conclusion: Impaired glucose metabolism in the brain was the key factor which was responsible for the elevated ( < 0.001) proteolysis leading to brain dysfunction.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据