期刊
INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE
卷 29, 期 5, 页码 529-536出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.ijdevneu.2011.04.001
关键词
Brain development; Magnetic resonance imaging; Growth rate; Prenatal; Cortex; Probabilistic atlas
资金
- National Institutes of Health through National Institute of Neurological Disorders and Stroke [R01 NS 061957, R01 NS 055064]
- National Center for Research Resources [UL1 RR024131]
- European Research Council [FP7/2007- 2013, 207667]
- [K23 NS52506-03]
- European Research Council (ERC) [207667] Funding Source: European Research Council (ERC)
In the latter half of gestation (20-40 gestational weeks), human brain growth accelerates in conjunction with cortical folding and the deceleration of ventricular zone progenitor cell proliferation. These processes are reflected in changes in the volume of respective fetal tissue zones. Thus far, growth trajectories of the fetal tissue zones have been extracted primarily from 2D measurements on histological sections and magnetic resonance imaging (MRI). In this study, the volumes of major fetal zones cortical plate (CP), subplate and intermediate zone (SP+ IZ), germinal matrix (GMAT), deep gray nuclei (DG), and ventricles (VENT) are calculated from automatic segmentation of motion-corrected, 3D reconstructed MRI. We analyzed 48 T2-weighted MRI scans from 39 normally developing fetuses in utero between 20.57 and 31.14 gestational weeks (GW). The supratentorial volume (STV) increased linearly at a rate of 15.22% per week. The SP + IZ (14.75% per week) and DG (15.56% per week) volumes increased at similar rates. The CP increased at a greater relative rate (18.00% per week), while the VENT (9.18% per week) changed more slowly. Therefore, CP increased as a fraction of STV and the VENT fraction declined. The total GMAT volume slightly increased then decreased after 25 GW. We did not detect volumetric sexual dimorphisms or total hemispheric volume asymmetries, which may emerge later in gestation. Further application of the automated fetal brain segmentation to later gestational ages will bridge the gap between volumetric studies of premature brain development and normal brain development in utero. Published by Elsevier Ltd on behalf of ISDN
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