期刊
INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE
卷 27, 期 1, 页码 59-64出版社
WILEY
DOI: 10.1016/j.ijdevneu.2008.09.200
关键词
Maternal deprivation; Object recognition; Social recognition; Galantamine; Donepezil; Acetylcholinesterase activity
资金
- CNPq
- FAPERGS, Brazil
Early postnatal maternal deprivation is known to cause long-lasting neurobiological effects. Here, we investigated whether some of the cognitive aspects of these deficits might be related to a disruption of the cholinergic system. Pregnant Wistar rats were individually housed and maintained on a 12:12 h light/dark cycle with food and water freely available. The mothers were separated from their pups for 3 h per day from postnatal day 1 (PND-1) to PND-10. To do that, the dams were moved to a different cage and the pups maintained in the original home cage, which was transferred to a different room kept at 32 C. After they reached 120-150 days of age, maternal-deprived and non-deprived animals were either sacrificed for brain acetylcholinesterase measurement, or trained and tested in an object recognition task and in a social recognition task as described by Rossato et al. (2007) [Rossato, J.I., Bevilaqua, L. R.M., Myskiw,J.C., Medina, J.H., Izquierdo, I., Cammarota, M. 2007. On the role hippocampal synthesis in the consolidation and reconsolidation of object recognition memory. Learn. Mem. 14,36-46] and Levy eta]. (2003) [Levy, F., Melo. A.I., Calef. B.G.Jr., Madden, M., Fleming. A.S. 2003. Complete maternal deprivation affects social, but not spatial, learning in adult rats. Dev. Psychobiol. 43, 177-191], respectively. There was increased acetylcholinesterase activity in hippocampus and perirhinal cortex of the deprived animals. In addition, they showed a clear impairment in memory of the two recognition tasks measured 24 h after training. Oral administration of the acetylcholinesterase inhibitors, donepezil or galantamine (1 mg/kg) 30 min before training reversed the memory impairments caused by maternal deprivation. The findings suggest that maternal deprivation affects memory processing at adulthood through a change in brain cholinergic systems. (C) 2008 ISDN. Published by Elsevier Ltd. All rights reserved.
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