期刊
INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY
卷 55, 期 4-5, 页码 483-494出版社
UNIV BASQUE COUNTRY UPV-EHU PRESS
DOI: 10.1387/ijdb.103226ia
关键词
angiogenesis; cancer; development; lymphangiogenesis; metastasis; signaling
资金
- NCCR Molecular Oncology of the Swiss National Science Foundation
- EU [LSHG-CT-2004-503573]
- Swiss National Science Foundation
The lymphatic system, also named the second vascular system, plays a critical role in tissue homeostasis and immunosurveillance. The past two decades of intensive research have led to the identification and detailed understanding of many molecular players and mechanisms regulating the formation of the lymphatic vasculature during embryonic development. Furthermore, clinical and experimental data clearly demonstrate that the formation of new lymphatic vessels by sprouting lymphangiogenesis from pre-existing lymphatic vessels, or by the de novo formation of lymphatic capillaries also occurs in various pathological conditions, such as cancer and organ transplant rejection, while lymphangiogenesis is non-functional in primary edema. In cancer, lymphatic vessels are one major gateway for invasive tumor cells to leave the primary tumor site and to establish distant organ metastasis. Therefore, the specific targeting of the lymphatic vasculature at the tumor site could be a promising approach to prevent metastasis formation.
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