期刊
INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY
卷 53, 期 5-6, 页码 707-716出版社
UNIV BASQUE COUNTRY UPV-EHU PRESS
DOI: 10.1387/ijdb.072495ip
关键词
gene regulatory network; cis-regulatory module; network subcircuit; sea urchin; development
资金
- Swiss National Science Foundation
- EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT [P01HD037105] Funding Source: NIH RePORTER
The development of multicellular organisms involves the partitioning of the organism into territories of cells of specific structure and function. The information for spatial patterning processes is directly encoded in the genome. The genome determines its own usage depending on stage and position, by means of interactions that constitute gene regulatory networks (GRNs). The GRN driving endomesoderm development in sea urchin embryos illustrates different regulatory strategies by which developmental programs are initiated, orchestrated, stabilized or excluded to define the pattern of specified territories in the developing embryo.
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