期刊
INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY
卷 52, 期 5-6, 页码 511-522出版社
UNIV BASQUE COUNTRY UPV-EHU PRESS
DOI: 10.1387/ijdb.072532mb
关键词
acrosome; sperm; zona binding; zona pellucida; sp56
资金
- U.S. National Institutes of Health [5 R01 HD041552, 1 P30 ES013508]
- Randolph-Macon College
- Fogarty International Center [5 D43 TW000671]
- EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH &HUMAN DEVELOPMENT [R01HD041552] Funding Source: NIH RePORTER
- FOGARTY INTERNATIONAL CENTER [D43TW000671] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES [P30ES013508] Funding Source: NIH RePORTER
Mammalian sperm must have properly formed acrosomes to be fully functional in the process of binding and penetrating the zona pellucida (ZP), the extracellular matrix surrounding the egg. There is much evidence to raise doubts about the old bag of enzymes paradigm of acrosomal function, although this is the model that seems to prevail. We concur with other scientists that acrosomal exocytosis is not an all or none event where the acrosome is either intact or reacted. As determined by transmission electron microscopy of human sperm undergoing acrosomal exocytosis, six stages can be identified, with the intermediate ones involving loss of acrosomal matrix material. In the mouse, there is a temporal relationship among four stages of acrosomal exocytosis. Numerous evidences suggest a more complex role for the acrosome in fertilization in which the acrosomal matrix is a scaffold for sperm-ZP interactions that self-regulates by a controlled disassembly mechanism.
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