期刊
INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY
卷 52, 期 5-6, 页码 607-613出版社
U B C PRESS
DOI: 10.1387/ijdb.072554bn
关键词
CatSper; KSper; Ca2+; hyperactivated sperm motility; patch clamp; sperm; Ca2+ channel
资金
- Howard Hughes Medical Institute Funding Source: Medline
- NHLBI NIH HHS [T32 HL007572] Funding Source: Medline
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [T32HL007572] Funding Source: NIH RePORTER
Whole-cell voltage clamp of mammalian spermatozoa was first achieved in 2006. This technical advance, combined with genetic deletion strategies, makes unambiguous identification of sperm ion channel currents possible. This review summarizes the ion channel currents that have been directly measured in mammalian sperm, and their physiological roles in fertilization. The predominant currents are a Ca2+-selective current requiring expression of the 4 mCatSper genes, and a rectifying K+ current with properties most similar to mSIo3. Intracellular alkalinization activates both channels and induces hyperactivated motility.
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