期刊
INTERNATIONAL JOURNAL OF CARDIOLOGY
卷 272, 期 -, 页码 4-10出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.ijcard.2018.09.070
关键词
Pulmonary hypertension; Inflammation; Transcription factors; Ion channels/ion channel diseases; Hypoxic pulmonary vasoconstriction; Genetics/epigenetics; Metabolic dysfunction; And the potential future role of histopathology
The European guidelines, which focus on clinical aspects of pulmonary hypertension (PH), provide only minimal information about the pathophysiological concepts of PH. Here, we review this topic in greater detail, focusing on specific aspects in the pathobiology, pathology and genetics, which include mechanisms of vascular inflammation, the role of transcription factors, ion channels/ion channel diseases, hypoxic pulmonary vasoconstriction, genetics/epigenetics, metabolic dysfunction, and the potential future role of histopathology of PH in the modern era of PH therapy. In addition to new insights in the pathobiology of this disease, this working group of the Cologne Consensus Conference also highlights novel concepts and potential new therapeutic targets to further improve the treatment options in PAH. (c) 2018 Published by Elsevier B.V.
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