期刊
INTERNATIONAL JOURNAL OF CARDIOLOGY
卷 176, 期 1, 页码 166-170出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.ijcard.2014.07.012
关键词
Particulate air pollution; Oxidative stress; Systemic inflammation; Effect modifier; Heart rate variability; Environmental health
资金
- U.S. EPA STAR grant [RD-83083801]
- NIH [ES00002]
Background: The role of oxidative stress and systemic inflammation on the association between personal exposures to ambient fine particulate matter <= 2.5 mu m in diameter (PM2.5) and cardiac autonomic dysfunction, indicated by reduction in heart rate variability (HRV), has not been examined. Methods: We performed a repeated measures study on community adults in a densely populated inner city neighborhood in Boston, Massachusetts. Continuous ambulatory electrocardiogram (ECG) monitoring and personal exposure to PM2.5 were measured for up to two consecutive days. Peripheral blood and spot urine samples were collected at 12-hour intervals for the measurements of markers of inflammation including C-reactive protein (CRP), fibrinogen, white blood cell (WBC) and platelet counts as well as for the analysis of urinary 8-hydroxy-2'-deoxyguanosine (8-OHdG), a marker of oxidative DNA damage. Results: After adjusting for confounders, we found a pronounced decrease in nighttime standard deviation of normal-to normal intervals (SDNN): an interquartile range (IQR) increase in PM2.5 (13.6 mu g/m(3)) was associated with an 8.4% decrease in SDNN (95% CI: -11.3 to -5.5). Compared with the lower eightieth percentile, significantly greater PM2.5 associated nighttime SDNN reductions were observed among subjects in the upper twentieth percentile of 8-OHdG by -25.3%, CRP by -24.9%, fibrinogen by -28.7%, WBC by -23.4%, and platelet counts by -24.0% (all P < 0.0001; all P-interaction < 0.01). Conclusions: These data suggest that oxidative stress and systemic inflammation exacerbate the adverse effects of PM2.5 on the cardiac autonomic function even at ambient levels of exposure. (C) 2014 Elsevier Ireland Ltd. All rights reserved
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