期刊
INTERNATIONAL JOURNAL OF CARDIOLOGY
卷 170, 期 3, 页码 270-277出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.ijcard.2013.11.010
关键词
Substance P; Tachykinin; Heart failure; Neuropeptide; Sensory nerve; Myocardial remodeling
资金
- National Heart, Lung and Blood Institute at the National Institutes of Health [R00-HL-093215, T32-HL007792]
The tachykinin, substance P, is found primarily in sensory nerves. In the heart, substance P-containing nerve fibers are often found surrounding coronary vessels, making them ideally situated to sense changes in the myocardial environment. Recent studies in rodents have identified substance P as having dual roles in the heart, depending on disease etiology and/or timing. Thus far, these studies indicate that substance P may be protective acutely following ischemia-reperfusion, but damaging long-term in non-ischemic induced remodeling and heart failure. Sensory nerves may be at the apex of the cascade of events leading to heart failure, therefore, they make a promising potential therapeutic target that warrants increased investigation. (C) 2013 Published by Elsevier Ireland Ltd.
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