4.6 Article

Miglitol, alpha-glycosidase inhibitor, reduces visceral fat accumulation and cardiovascular risk factors in subjects with the metabolic syndrome: A randomized comparable study

期刊

INTERNATIONAL JOURNAL OF CARDIOLOGY
卷 167, 期 5, 页码 2108-2113

出版社

ELSEVIER IRELAND LTD
DOI: 10.1016/j.ijcard.2012.05.109

关键词

Post-prandial hyperglycemia; Visceral obesity; Insulin resistance; Endothelial function

资金

  1. Ministry of Education, Culture, Sports, Science and Technology
  2. Ministry of Health, Labour and Welfare (MHLW)
  3. Suzuken Memorial Foundation

向作者/读者索取更多资源

Background/objectives: Visceral fat obesity plays an essential role in the clustering of cardiovascular risk factors. This study aimed to clarify the effects of miglitol, alpha-glycosidase inhibitor, on body weight, fat distribution and cardiovascular risk factors in patients with the metabolic syndrome. Methods and results: One hundred and eleven drug naive patients with the metabolic syndrome were continuously recruited and randomly allocated to a group of life style modification (LSM) alone or a group of LSM with miglitol per os 50 mg x 3 (LSM + miglitol). After 12 weeks of treatment, body weight (5.1%), body mass index (4.9%) and waist circumference were greatly reduced in miglitol group (n=42) than in LSM group (n=43). Plasma levels of insulin and glucose during an oral 75 g glucose loading were decreased only in miglitol group. Visceral fat area, determined by abdominal computed tomography, was greatly reduced in miglitol group (baseline 188 vs 12 weeks 161 cm(2), p<0.0001) than in LSM group (184 vs 174 cm(2), p<0.05). Subcutaneous fat area was reduced only in miglitol group (p<0.001). Systolic blood pressure was reduced in miglitol group (142 vs 133 mm Hg, p<0.001), but not in control group (137 vs 134 mm Hg). Serum levels of triglyceride, LDL-cholesterol, gamma-GTP, and high-sensitive CRP were decreased and adiponectin was increased only in miglitol group. Conclusions: Our results indicated that miglitol showed an anti-obesity potential, which was achieved by reducing abdominal fat accumulation and/or enhanced insulin requirement, and then corrected both the metabolic and hemodynamic aberrations seen in patients with the metabolic syndrome (UMIN Clinical Trial Registry UMIN000007650). (C) 2012 Elsevier Ireland Ltd. All rights reserved.

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