期刊
INTERNATIONAL JOURNAL OF CANCER
卷 136, 期 7, 页码 1718-1730出版社
WILEY
DOI: 10.1002/ijc.29163
关键词
HSV; bevacizumab; oncolytic herpes virus HF10; angiogenesis inhibitor
类别
资金
- Nitto Foundation
- Grants-in-Aid for Scientific Research [25293275] Funding Source: KAKEN
Breast cancer is one of the most common and feared cancers faced by women. The prognosis of patients with advanced or recurrent breast cancer remains poor despite refinements in multimodality therapies involving chemotherapeutic and hormonal agents. Multimodal therapy with more specific and effective strategy is urgently needed. The oncolytic herpes simplex virus (HSV) has potential to become a new effective treatment option because of its broad host range and tumor selective viral distribution. Bevacizumab is a monoclonal antibody against VEGFA, which inhibits angiogenesis and therefore tumor growth. Our approach to enhance the antitumor effect of the oncolytic HSV is to combine oncolytic HSV HF10 and bevacizumab in the treatment of breast cancer. Our results showed that bevacizumab enhanced viral distribution as well as tumor hypoxia and expanded the population of apoptotic cells and therefore induced a synergistic antitumor effect. HF10 is expected to be a promising agent in combination with bevacizumab in the anticancer treatment.
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