相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。PI3K/mTOR Inhibitor PF-04691502 Antitumor Activity Is Enhanced with Induction of Wild-Type TP53 in Human Xenograft and Murine Knockout Models of Head and Neck Cancer
Amanda Herzog et al.
CLINICAL CANCER RESEARCH (2013)
Molecular Pathways: Involving Microenvironment Damage Responses in Cancer Therapy Resistance
Yu Sun et al.
CLINICAL CANCER RESEARCH (2012)
Genetic Variants in the PI3K/PTEN/AKT/mTOR Pathway Predict Head and Neck Cancer Patient Second Primary Tumor/Recurrence Risk and Response to Retinoid Chemoprevention
Michelle A. T. Hildebrandt et al.
CLINICAL CANCER RESEARCH (2012)
Alteration of Cellular Behavior and Response to PI3K Pathway Inhibition by Culture in 3D Collagen Gels
Brian Fallica et al.
PLOS ONE (2012)
EGFR-PI3K-AKT-mTOR signaling in head and neck squamous cell carcinomas: attractive targets for molecular-oriented therapy
Christian Freudlsperger et al.
EXPERT OPINION ON THERAPEUTIC TARGETS (2011)
Radioresistance of glioma stem cells: Intrinsic characteristic or property of the 'microenvironment-stem cell unit'?
Mariella Mannino et al.
MOLECULAR ONCOLOGY (2011)
Tumor-Host Interactions: A Far-Reaching Relationship
Sandra S. McAllister et al.
JOURNAL OF CLINICAL ONCOLOGY (2010)
Preclinical model of organotypic culture for pharmacodynamic profiling of human tumors
Valentina Vaira et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Cancer and the tumor microenvironment: a review of an essential relationship
Flaubert Mbeunkui et al.
CANCER CHEMOTHERAPY AND PHARMACOLOGY (2009)
EGFRvIII and DNA Double-Strand Break Repair: A Molecular Mechanism for Radioresistance in Glioblastoma
Bipasha Mukherjee et al.
CANCER RESEARCH (2009)
The level of AKT phosphorylation on threonine 308 but not on serine 473 is associated with high-risk cytogenetics and predicts poor overall survival in acute myeloid leukaemia
N. Gallay et al.
LEUKEMIA (2009)
Dysregulated molecular networks in head and neck carcinogenesis
Alfredo A. Molinolo et al.
ORAL ONCOLOGY (2009)
EGFR inhibition as a therapy for head and neck squamous cell carcinoma
Judith Loeffler-Ragg et al.
EXPERT OPINION ON INVESTIGATIONAL DRUGS (2008)
Activation of the PI3-K/AKT pathway and implications for radioresistance mechanisms in head and neck cancer
Johan Bussink et al.
LANCET ONCOLOGY (2008)
Specific activation of the different fibrogenic cells in rat cultured liver slices mimicking in vivo situations
Christelle Guyot et al.
VIRCHOWS ARCHIV (2007)
Role of p53 up-regulated modulator of apoptosis and phosphorylated Akt in melanoma cell growth, apoptosis, and patient survival
Alison M. Karst et al.
CANCER RESEARCH (2006)
Mutant epidermal growth factor receptor (EGFRvIII) contributes to head and neck cancer growth and resistance to EGFR targeting
John C. Sok et al.
CLINICAL CANCER RESEARCH (2006)
Ras, PI(3)K and mTOR signalling controls tumour cell growth
Reuben J. Shaw et al.
NATURE (2006)
Patterns of cancer incidence, mortality, and prevalence across five continents: Defining priorities to reduce cancer disparities in different geographic regions of the world
Farin Kamangar et al.
JOURNAL OF CLINICAL ONCOLOGY (2006)
Evaluation of two phosphorylation sites improves the prognostic significance of Akt activation in non-small-cell lung cancer tumors
J Tsurutani et al.
JOURNAL OF CLINICAL ONCOLOGY (2006)
Development of an in vitro multicellular tumor spheroid model using microencapsulation and its application in anticancer drug screening and testing
XL Zhang et al.
BIOTECHNOLOGY PROGRESS (2005)
MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks
M Stucki et al.
CELL (2005)
Akt activation correlates with adverse outcome in tongue cancer
E Massarelli et al.
CANCER (2005)
Prognostic value of activated Akt expression in oral squamous cell carcinoma
J Lim et al.
JOURNAL OF CLINICAL PATHOLOGY (2005)
Expression of protein tyrosine kinases in head and neck squamous cell carcinomas
WM Ongkeko et al.
AMERICAN JOURNAL OF CLINICAL PATHOLOGY (2005)
Mutant epidermal growth factor receptor displays increased signaling through the phosphatidylinositol-3 kinase/AKT pathway and promotes radioresistance in cells of astrocytic origin
B Li et al.
ONCOGENE (2004)
PI3K/Akt and apoptosis: size matters
TF Franke et al.
ONCOGENE (2003)
EGFRvIII-mediated radioresistance through a strong cytoprotective response
G Lammering et al.
ONCOGENE (2003)
Drug resistance and the microenvironment: nature and nurture
PJ Morin
DRUG RESISTANCE UPDATES (2003)
β4 integrin-dependent formation of polarized three-dimensional architecture confers resistance to apoptosis in normal and malignant mammary epithelium
VM Weaver et al.
CANCER CELL (2002)
Ionizing radiation activates Erb-B receptor dependent Akt and p70 S6 kinase signaling in carcinoma cells
JN Contessa et al.
ONCOGENE (2002)
Medical progress - Head and neck cancer
A Forastiere et al.
NEW ENGLAND JOURNAL OF MEDICINE (2001)
The PI3K-PDK1 connection: more than just a road to PKB
B Vanhaesebroeck et al.
BIOCHEMICAL JOURNAL (2000)