期刊
INTERNATIONAL JOURNAL OF CANCER
卷 135, 期 3, 页码 541-550出版社
WILEY
DOI: 10.1002/ijc.28707
关键词
clinicopathological feature; microRNA-224; biochemical recurrence-free survival; TRIB1; prostate cancer
类别
资金
- National Natural Science Foundation of China [81170699, 81272813, 81200550]
- Science and Technology Project of Guangdong Province [2012B031800008]
- Medical Research Fund of Guangdong Province [A2012489]
- Guangzhou Municipal Science and Technology Key Project [11C23150711]
- Bureau of Health in Guangzhou Municipality [201102A212015]
Our previous microarray data showed that microRNA-224 (miR-224) was downregulated in human prostate cancer (PCa) tissues compared with adjacent benign tissues. However, the underlying mechanisms by which miR-224 is involved in PCa remain unclear. In this study, we identified TRIB1 as a target gene of miR-224. Forced expression of miR-224 suppressed PCa cell proliferation, invasion and migration, and promoted cell apoptosis by downregulating TRIB1. Moreover, the expression level of miR-224 in PCa tissues was negatively correlated with that of TRIB1. miR-224 downregulation was frequently found in PCa tissues with metastasis, higher PSA level and clinical stage, whereas TRIB1 upregulation was significantly associated with metastasis. Both miR-224 downregulation and TRIB1 upregulation were significantly associated with poor biochemical recurrence-free survival of patients with PCa. In conclusion, these findings reveal that the aberrant expression of miR-224 and TRIB1 may promote PCa progression and have potentials to serve as novel biomarkers for PCa prognosis.
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