期刊
INTERNATIONAL JOURNAL OF CANCER
卷 137, 期 10, 页码 2275-2286出版社
WILEY
DOI: 10.1002/ijc.29073
关键词
hippo; yap; cancer; therapy
类别
资金
- National Natural Science Foundation of China [81372615]
- Shanghai Science and Technology Development Fund [12140902300, 12410707400]
- Shanghai Health System Outstanding Young Talent Training Plan [XYQ2013118]
- Tongji University Outstanding Youth Program [1501219074]
In the past decades, the Hippo signaling pathway has been delineated and shown to play multiple roles in the control of organ size in both Drosophila and mammals. In mammals, the Hippo pathway is a kinase cascade leading from Mst1/2 to YAP and its paralog TAZ. Several studies have demonstrated that YAP/TAZ is a candidate oncogene and that other members of the Hippo pathway are tumor suppressive genes. The dysregulation of the Hippo pathway has been observed in a variety of cancers. This review chronicles the recent progress in elucidating the function of Hippo signaling in tumorigenesis and provide a rich source of potential targets for cancer therapy.
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