期刊
INTERNATIONAL JOURNAL OF CANCER
卷 131, 期 12, 页码 2839-2851出版社
WILEY-BLACKWELL
DOI: 10.1002/ijc.27582
关键词
cancer vaccine; metastasis; carcinoembryonic antigen; antibody-dependent cytotoxicity
类别
资金
- Canadian Breast Cancer Foundation
- University of Toronto Research Program
Metastatic forms of cancers remain the main cause of death in cancer patients. In this study, we demonstrate that directing a sustained antibody response towards the homotypic binding function of CEA interferes with the implantation and development of tumor foci in CEA-expressing transgenic (CEA.Tg) mice. Specifically, vaccinating CEA.Tg mice with a recombinant, altered self-form of the CEA Ig V-like N domain led to the production of circulating IgG1 and IgG2a antibodies that inhibited CEA-mediated adhesion of murine carcinoma expressing CEA (MC38.CEA) and mediated antibody-dependent lysis of tumor cells. Moreover, vaccinated CEA.Tg mice were resistant to the development of tumor nodules in the lungs and the peritoneal cavity, suggesting that mounting a focused antibody response to the CEA N domain may represent a simple therapeutic strategy to control the establishment of metastatic foci in cancer patients.
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