期刊
INTERNATIONAL JOURNAL OF CANCER
卷 131, 期 11, 页码 2499-2508出版社
WILEY
DOI: 10.1002/ijc.27550
关键词
carcinoma; stroma; myofibroblast; actin; lectin
类别
资金
- Ministry of Education, Youth and Sports of the Czech Republic [NPVII 2B06106]
- Academy of Sciences of the Czech Republic [AV0Z50520514]
- Charles University project for Specific University Research [264510]
- Charles University project UNCE [204013]
- Charles University [PRVOUK/1LF/1]
- EC research program GlycoHIT [260600]
Tumor stroma is an active part influencing the biological properties of malignancies via molecular cross-talk. Cancer-associated fibroblasts play a significant role in this interaction. These cells frequently express smooth muscle actin and can be classified as myofibroblasts. The adhesion/growth-regulatory lectin galectin-1 is an effector for their generation. In our study, we set the presence of smooth muscle actin-positive cancer-associated fibroblasts in relation to this endogenous lectin and an in vivo competitor (galectin-3). In squamous cell carcinomas of head and neck, upregulation of galectin-1 presence was highly significantly correlated to presence of smooth muscle actin-positive cancer-associated fibroblasts in the tumor (p = 4 x 10-8). To pinpoint further correlations on the molecular level, we applied microarray analyses to the transcription profiles of the corresponding tumors. Significant correlations of several transcripts were detected with the protein level of galectin-1 in the cancer-associated fibroblasts. These activated genes (MAP3K2, TRIM23, PTPLAD1, FUSIP1, SLC25A40 and SPIN1) are related to known squamous-cell-carcinoma poor-prognosis factors, NF-kappa B upregulation and splicing downregulation. These results provide new insights into the significance of presence of myofibroblasts in squamous cell carcinoma.
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