期刊
INTERNATIONAL JOURNAL OF CANCER
卷 131, 期 11, 页码 2487-2498出版社
WILEY
DOI: 10.1002/ijc.27548
关键词
perifosine; curcumin; colorectal cancer; apoptosis; signal transduction
类别
资金
- National Natural Science Foundation [81101801, 81101676]
- Natural Science Foundation of Jiangsu Province [BK2010160, BK2011374]
- Foundation of Wuxi Health Bureau [ZD1008]
Our study shows that coadministration of curcumin and an orally bioactive alkylphospholipid perifosine results in a significant increase in colorectal cancer cell apoptosis and a marked inhibition of cell growth both in vitro and in vivo. This novel combinatorial regimen leads to changes of multiple cell signaling pathways including inactivation of Akt and nuclear factor-?B as well as activation of c-Jun N-terminal kinases and endoplasmic reticulum stress. Further, perifosine and curcumin synergistically increase intracellular level of reactive oxygen species and ceramide, and downregulate the expression of cyclin D1 and Bcl-2 in colorectal cancer cells. These changes at molecular level together account for the cancer cell apoptosis and growth inhibition. We conclude that perifosine sensitizes colorectal cancer cells to curcumin by modulating multiple signaling pathways. Adding perifosine with curcumin may represent an effective therapy regimen against colorectal cancers, and possible other aggressive tumors.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据