期刊
INTERNATIONAL JOURNAL OF CANCER
卷 131, 期 8, 页码 1863-1873出版社
WILEY
DOI: 10.1002/ijc.27467
关键词
E-cadherin; ss-catenin; vimentin; EMT; nasopharyngeal carcinoma; prognosis
类别
资金
- National Natural Science Foundation of China-Guangdong Joint Fund [u0732006]
- National 973 Basic Research Program of China [2011CB504800]
- National 863 High Technology Research and Development program of China [2006AA02A404]
Expression of vimentin and the epithelial to mesenchymal transition (EMT) markers E-cadherin, beta-catenin is essential for the progression of various human cancers. Our study aimed to investigate the aberrant localization E-cadherin, beta-catenin and vimentin, and their prognostic significance in 122 nasopharyngeal carcinoma (NPC) patients by immunohistochemistry and immunofluorescence. Our results showed that both membranous and cytoplasmic localization of E-cadherin staining were associated with lymph node metastasis (p = 0.000 and 0.005, respectively) and clinical stage (p = 0.000 and 0.007, respectively). High cytoplasmic beta-catenin correlated significantly with larger tumor size (p = 0.020), lymph node metastasis (p = 0.000) and advanced clinical stage (p = 0.036). However, no significant difference was observed between membranous beta-catenin and clinicopathologic features (p = 0.05). High nuclear vimentin expression correlated significantly with positive lymph node metastasis (p = 0.000) and advanced clinical stage (p = 0.000). Multivariate analysis showed that nuclear vimentin and cytoplasmic E-cadherin were independent prognostic factors (p = 0.016 and 0.001, respectively), as well as M classification (p = 0.001). More importantly, patients with high coexpression of nuclear vimentin and cytoplasmic E-cadherin had shorter survival time (p = 0.000). Furthermore, high coexpression of these two proteins was closely associated with lymph node metastasis (p = 0.000) and advanced clinical stage (p = 0.000). Our studies provide convincing evidence that EMT may play an important role in the biological progression of NPC, and nuclear vimentin and cytoplasmic E-cadherin might have independent prognostic value in NPC patients and serve as novel targets for prognostic therapeutics.
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