期刊
INTERNATIONAL JOURNAL OF CANCER
卷 131, 期 5, 页码 1187-1196出版社
WILEY
DOI: 10.1002/ijc.27327
关键词
prostate cancer; vitamin D; 25-hydroxyvitamn D
类别
资金
- World Cancer Research Fund [2006/15]
- Cancer Research UK Graduate Training Fellowship [C31211/A10095]
- UK Department of Health (NIHR Health Technology Assessment program)
- UK Department of Health
- National Cancer Research Institute (NCRI)
- Medical Research Council [G0801462, G0900871] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0509-10242] Funding Source: researchfish
- MRC [G0900871] Funding Source: UKRI
Epidemiological studies suggest that vitamin D protects against prostate cancer, although evidence is limited and inconsistent. We investigated associations of circulating total 25-hydroxyvitamin D (25(OH)D) with prostate specific antigen-detected prostate cancer in a case-control study nested within the prostate testing for cancer and treatment (ProtecT) trial. Conditional logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) quantifying the association between circulating total 25(OH)D and prostate cancer. In case-only analyses, we used unconditional logistic regression to quantify associations of total 25(OH)D with stage (advanced vs. localized) and Gleason grade (high-grade (=7) vs. low-grade (<7)). Predetermined categories of total 25(OH)D were defined as: high: =30 ng/mL; adequate: 20 <30 ng/mL; insufficient: 12 <20 ng/mL; deficient: <12 ng/mL. Fractional polynomials were used to investigate the existence of any U-shaped relationship. We included 1,447 prostate cancer cases (153 advanced, 469 high-grade) and 1,449 healthy controls. There was evidence that men deficient in vitamin D had a 2-fold increased risk of advanced versus localized cancer (OR for deficient vs. adequate total 25(OH)D = 2.33, 95% CI: 1.26, 4.28) and high-grade versus low-grade cancer (OR for deficient vs. adequate total 25(OH)D = 1.78, 95% CI: 1.15, 2.77). There was no evidence of a linear association between total 25(OH)D and prostate cancer (p = 0.44) or of an increased risk of prostate cancer with high and low vitamin D levels. Our study provides evidence that lower 25(OH)D concentrations were associated with more aggressive cancers (advanced versus localized cancers and high- versus low-Gleason grade), but there was no evidence of an association with overall prostate cancer risk.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据