期刊
INTERNATIONAL JOURNAL OF CANCER
卷 124, 期 3, 页码 511-515出版社
WILEY
DOI: 10.1002/ijc.24064
关键词
apoptosis; cancer; death receptor; mitochondria; IAPs
类别
资金
- Deutsche Forschungsgemeinschaft
- Deutsche Krebshilfe
- Bundesministerium fur Forschung und Technologie
- Wilhelm-Sander-Stiftung
- Else-Kroner Stiftung
- European Community
- DAAD/INCA
- Interuniversity Attraction Pole [IAP6/18]
One of the hallmarks of human cancers is the intrinsic or acquired resistance to apoptosis. Evasion of apoptosis may contribute to carcinogenesis, tumor progression and also to treatment resistance, since most current anticancer therapies including chemotherapy, radio- and immunotherapy primarily act by activating cell death pathways including apoptosis in cancer cells. Hence, a better understanding of the molecular mechanisms underlying tumor resistance to apoptotic cell death is expected to provide the basis for a rational approach to develop molecular targeted therapies. (C) 2008 Wiley-Liss, Inc.
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