期刊
INTERNATIONAL JOURNAL OF CANCER
卷 124, 期 1, 页码 239-244出版社
WILEY
DOI: 10.1002/ijc.23881
关键词
tumor microenvironment; immune escape
类别
资金
- National Institute of Health
- Doris Duke Charitable Foundation
- Lymphoma Research Foundation
- American Society of Clinical Oncology Young Investigator
- Deutsche Krebshilfe, Germany
There has been accumulating evidence that CD4(+)CD25(+) FoxP3 expressing regulatory T cells (Treg) are highly concentrated in tumors, thereby fostering an immune-privileged microenvironment. Some studies have shown that T-cell receptor (TCR) stimulation can convert conventional T cells into Treg. Follicular lymphoma (FL) It cells can enhance this Treg conversion. We investigated whether FL tumor B cells, as opposed to normal B cells, are unique in their ability to convert effector T cells into Treg. We found that tumor B cells alone, without artificial TCR stimulation, could induce conventional T cells to express FoxP3 and to acquire regulatory function. In contrast to their malignant counterpart, normal It cells did not induce Treg conversion. Treg conversion was independent of the T cell background, as T cells isolated from FL or normal peripheral blood were equally susceptible to being converted by tumor B cells. Our study provides evidence for a tumor-specific mechanism by which FL tumor cells promote immune escape through the induction of Treg. (C) 2008 Wiley-Liss, Inc.
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