期刊
INTERNATIONAL JOURNAL OF CANCER
卷 124, 期 9, 页码 2179-2185出版社
WILEY
DOI: 10.1002/ijc.24168
关键词
TRITI; isopentellyl transferase; microarray; tumour suppressor; antitumoural
类别
资金
- UE [LSHM-CT2005-018652]
- Associazione and Fondazione Italiana Ricerca Cancro
- MIUR [PRIN 2006069030003]
N-6-isopentenyladenosine (i(6)A), a member of the cytokinin family of plant hormones, has potent in vitro antitumour activity in different types or human epithelial cancer cell lines. Gene expression profile. analysis of i(6)A-treated cells revealed induction of genes (e.g., PPP1R15A, DNA,1139, DDIT3, and HBP1) involved in the negative regulation of cell cycle progression and reportedly up regulated during cell cycle arrest in stress conditions. Of 6 1 A analogues synthesized, only the I with a saturated double bond of the isopentenyl side chain had in vitro antitumour activity, although weaker than that of i(6)A, suggesting that i(6)A biological activity is highly linked to its structure. In vivo analysis of i(6)A and the active analogue revealed no significant inhibition of cancer cell growth in mice by either reagent. Thus, although i(6)A may, inhibit cell proliferation by regulating the cell cycle, further studies are needed to identify, active analogues potentially, useful in vivo. (C) 2008 Wiley-Liss. Inc.
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