期刊
INTERNATIONAL JOURNAL OF CANCER
卷 123, 期 9, 页码 2148-2151出版社
WILEY-LISS
DOI: 10.1002/ijc.23566
关键词
circadian clock; night-time shift work; non-Hodgkin lymphoma
类别
资金
- Academy of Finland [210262]
- Academy of Finland (AKA) [210262, 210262] Funding Source: Academy of Finland (AKA)
Our aim was to find out whether non-Hodgkin lymphoma (NHL) was more common than expected among night-time shift workers. The Finnish job-exposure matrix (FINJEM) provided estimates of the proportion of exposed persons and the mean level of exposure among the exposed in each occupation. The probability of night-time work in each occupation was assessed, the observed and expected numbers of cancer cases in a cohort of persons born in 1906-1945 during the years of 1971-1995 were calculated, and the cumulative index of night-time work was scored. The cohort compromised of 1,669,272 persons of whom 6,307 (3,813 men and 2,494 women) had NHL during the follow-up. Night-time work increased significantly (p = 0.01) the risk of NHL in men, the overall relative risk being 1.10 (95% confidence interval of 1.03-1.19). Using the lag period of 10 years, the risk ratio was 1.28 (1.03-1.59) for men who worked in night-time shifts to a high degree as compared with those who had not been exposed to night-time work. Night-time workers are cancer prone and have a greater risk of NHL than population on average. (c) 2008 Wiley-Liss, Inc.
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