期刊
INTERNATIONAL JOURNAL OF CANCER
卷 123, 期 10, 页码 2327-2330出版社
WILEY-LISS
DOI: 10.1002/ijc.23789
关键词
lung adenocarcinoma; smoking; genetic susceptibility; single-nucleotide polymorphisms; genome-wide association
类别
资金
- Associazione and Fondazione Italiana Ricerca Cancro (AIRC and FIRC)
- Fondo Investimenti Ricerca di Base (FIRB), Italy
- CEGEN (Spanish National Genotyping Centre), CNIO Node, Spain
Genome-wide screening for genetic loci associated with risk of lung adenocarcinoma (ADCA) was carried out in pooled DNA using the Illumina 300K single-nucleotide polymorphism (SNIP) array, in a joint analysis of 2 Italian case-control series matched by age, gender and smoking habit. The rare allele carrier status of 8 SNPs was associated with a decreased lung ADCA risk [odds ratios (OR): 0.6-0.8]. In a polygenic model characterized by additive and interchangeable effects, individuals carrying 2 to 6 rare alleles at these 8 SNPs showed a significant trend toward a decreased risk of lung ADCA (up to OR of 0.3). These results suggest the relevance of a polygenic model in the modulation of individual risk of lung ADCA in the general population. (C) 2008 Wiley-Liss. Inc.
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