期刊
INTERNATIONAL JOURNAL OF CANCER
卷 123, 期 9, 页码 2041-2047出版社
WILEY-LISS
DOI: 10.1002/ijc.23726
关键词
desmosome; hepsin; ovarian cancer; serine protease
类别
资金
- Department of Defense OCRP Training Program Award [DAMD17-03-1-0161]
- Joan's Legacy Foundation
- NIH [RO1CA103924]
- Ovarian Cancer Research Fund (OCRF) Program Project Development Grant
Hepsin is a serine protease that is widely expressed in different tissues and cell types, most prominently in the normal liver and kidney. Overexpression of hepsin has been associated with prostate cancers, ovarian cancers and renal cell carcinomas. The physiological functions of hepsin in normal tissues and tumors are poorly understood. To gain insight into its function in ovarian cancer, we analyzed the expression and subcellular localization of hepsin protein in ovarian cancer cell lines and tumors. We showed that the membrane-associated hepsin protein is present at desmosomal junctions, where it colocalizes with its putative proteolytic substrate hepatocyte growth factor. Consistent with the growing evidence that desmosomal junctions and their constituents play a role in cancer progression, we demonstrated that overexpression of hepsin promotes ovarian tumor growth in a mouse model. The ability of ectopic hepsin to induce tumor growth in mice is abrogated by the mutation of 3 critical residues in the catalytic domain, thus implicating the enzymatic activity of hepsin in promoting tumor progression. (c) 2008 Wiley-Liss, Inc.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据