期刊
INTERNATIONAL JOURNAL OF BIOSTATISTICS
卷 7, 期 1, 页码 -出版社
BERKELEY ELECTRONIC PRESS
DOI: 10.2202/1557-4679.1278
关键词
binary outcome; log binomial regression; randomized controlled trial; relative risk; simulation
资金
- Commonwealth
- Australian Postgraduate Award
The relative risk is a clinically important measure of the effect of treatment on binary outcomes in randomized controlled trials (RCTs). An adjusted relative risk can be estimated using log binomial regression; however, convergence problems are common with this model. While alternative methods have been proposed for estimating relative risks, comparisons between methods have been limited, particularly in the context of RCTs. We compare ten different methods for estimating relative risks under a variety of scenarios relevant to RCTs with independent observations. Results of a large simulation study show that some methods may fail to overcome the convergence problems of log binomial regression, while others may substantially overestimate the treatment effect or produce inaccurate confidence intervals. Further, conclusions about the effectiveness of treatment may differ depending on the method used. We give recommendations for choosing a method for estimating relative risks in the context of RCTs with independent observations.
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