期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
卷 10, 期 5, 页码 520-529出版社
IVYSPRING INT PUBL
DOI: 10.7150/ijbs.8879
关键词
macrophage polarization; alternatively activated macrophage; signal pathways; inflammatory diseases; immune regulation
资金
- National Natural Science Foundation [81130035, 81372054, 81272090, 81121004]
- National Basic Research Program of China [2012CB518102]
- Medical Research Foundation of Chinese PLA [AWS11J008, BWS12J050]
Diversity and plasticity are two hallmarks of macrophages. M1 macrophages (classically activated macrophages) are pro-inflammatory and have a central role in host defense against infection, while M2 macrophages (alternatively activated macrophages) are associated with responses to anti-inflammatory reactions and tissue remodeling, and they represent two terminals of the full spectrum of macrophage activation. Transformation of different phenotypes of macrophages regulates the initiation, development, and cessation of inflammatory diseases. Here we reviewed the characters and functions of macrophage polarization in infection, atherosclerosis, obesity, tumor, asthma, and sepsis, and proposed that targeting macrophage polarization and skewing their phenotype to adapt to the microenvironment might hold great promise for the treatment of inflammatory diseases.
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