期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
卷 10, 期 6, 页码 596-601出版社
IVYSPRING INT PUBL
DOI: 10.7150/ijbs.8780
关键词
Adrenal androgens; Backdoor Pathway; Prostate cancer; Dihydrotestosterone; CYP17A1
Almost all men who present with advanced prostate cancer (CaP) and many men who fail potentially curative therapy are treated with androgen deprivation therapy (ADT). ADT is not curative and CaP recurs as the lethal phenotype. The goal of this review is to describe the evolution of adrenal androgen blockade, how new androgen measurement methods have furthered understanding of androgen metabolism, and how further understanding of the backdoor pathway of androgen metabolism may lead to interventions that extend survival even more.
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