期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
卷 7, 期 3, 页码 347-363出版社
IVYSPRING INT PUBL
DOI: 10.7150/ijbs.7.347
关键词
Radiation-induced carcinogenesis; Radiation induced thymic lymphoma; MicroRNA; miR-21; Big-h3; TGF beta
资金
- National Natural Science Foundation of China [31070761]
- Natural Science Foundation of Shanghai, China [09ZR1439400]
Dysregulation of certain microRNAs (miRNAs) in cancer can promote tumorigenesis, metastasis and invasion. However, the functions and targets of only a few mammalian miRNAs are known. In particular, the miRNAs that participates in radiation induced carcinogenesis and the miRNAs that target the tumor suppressor gene Big-h3 remain undefined. Here in this study, using a radiation induced thymic lymphoma model in BALB/c mice, we found that the tumor suppressor gene Big-h3 is down-regulated and miR-21 is up-regulated in radiation induced thymic lymphoma tissue samples. We also found inverse correlations between Big-h3 protein and miR-21 expression level among different tissue samples. Furthermore, our data indicated that miR-21 could directly target Big-h3 in a 3'UTR dependent manner. Finally, we found that miR-21 could be induced by TGF beta and miR-21 has both positive and negative effects in regulating TGF beta signaling. We conclude that miR-21 participates in radiation induced carcinogenesis and it regulates TGF beta signaling.
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