期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
卷 7, 期 5, 页码 567-574出版社
IVYSPRING INT PUBL
DOI: 10.7150/ijbs.7.567
关键词
gastric cancer; cell proliferation; miR-148a; p27
资金
- Chinese National Key Program on Basic Research [2011CB504200, 2011CB901601]
- Chinese Key Program for Drug Invention [2009ZX09501-027]
- Chinese Key Project for the Infections Disease [2009ZX10002-016]
- National Natural Science Foundation of China [31030040, 30700423, 30900863]
- Beijing Natural Science Foundation of China [5082018]
Accumulating evidence has shown that miRNAs are aberrantly expressed in human gastric cancer and crucial to tumorigenesis. Herein, we identified the role of miR-148a in gastric cell proliferation. miR-148a knockdown inhibited cell proliferation in gastric cancer cell lines. Conversely, miR-148a overexpression promoted cell proliferation and cell cycle progression. p27, a key inhibitor of cell cycle, was verified as the target of miR-148a, indicating miR-148a might downregulate p27 expression to promote gastric cell proliferation. Moreover, we confirmed that miR-148a expression was frequently and dramatically downregulated in human advanced gastric cancer tissues, and observed a good inverse correlation between miR-148a and p27 expression in tumor samples. Thus, our results demonstrated that miR-148a downregulation might exert some sort of antagonistic function in cell proliferation, rather than promote cell proliferation in gastric cancer.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据