期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
卷 7, 期 6, 页码 762-768出版社
IVYSPRING INT PUBL
DOI: 10.7150/ijbs.7.762
关键词
Mesenchymal stem cells; MicroRNA; Hypoxia/serum deprivation; Apoptosis
资金
- National Natural Science Foundation of China [30770862, 30871024]
- Major National Basic Research Program in the People's Republic of China (Program 973) [2010CB529508, 2007CB512108, 2005CB724600]
The use of bone marrow mesenchymal stem cell- (MSC) transplantation therapy for cardiac diseases is limited due to poor survival of implanted cells. MicroRNAs (miRNAs) have been reported to be involved in regulating almost all cellular processes, including apoptosis. In this study, we found that the miRNA profile was altered during apoptosis induced by hypoxia and serum deprivation (hypoxia/SD). We further revealed that over-expression of miR-21, miR-23a and miR-210 could promote the survival of MSCs exposed to hypoxia/SD. In contrast, down-regulation of miR-21, miR-23a and miR-503 aggravated apoptosis of MSCs. It was indicated that these miRNAs may play important roles during MSC apoptosis induced by hypoxia/SD.
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