A review on versatile applications of blends and composites of pullulan with natural and synthetic polymers

Pullulan is a non-ionic, linear, water-soluble and a neutral polysaccharide. It is composed of alpha-(1,6) repeated maltotriose units via alpha-(1,4) glycosidic bond having chemical formula (C6H10O5)(n). It shows non-immunogenic, non-toxic, non-carcinogenic and non-mutagenic properties. It is used in food edible coatings, films, as flocculant, foaming agent and adhesive. It may also be used as a carrier for bioactive compounds and a protective packaging for food and pharmaceutical products. Therefore, it is blended with different polymers such as carrageenan, mucilages, chitosan, cellulose, sodium alginate, starch, polyethyleneimine, whey-protein, polyisopropylacrylamide, histone, jeffamine, polyamidoamine, pemulen, hyaluronic add, polyvinyl alcohol and caboxymethyl cellulose. In this article, a comprehensive overview of combination of pullulan with natural and synthetic polymers and their applications in biomedical field involving drug delivery system, tissue engineering, wound healing and gene therapy, is presented. It also describes the utilization of pullulan based materials in food industry, water treatment and pharmaceutical industry. All the technical scientific issues have been addressed; highlighting the recent advancements.(C) 2018 Elsevier B.V. All rights reserved.