期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
卷 129, 期 -, 页码 1127-1132出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijbiomac.2018.09.099
关键词
Chitosan; Quaternary; Antifungal
资金
- National Natural Science Foundation of China [41576156]
- Natural Science Foundation of Shandong Province of China [ZR2017BD015]
- Yantai Science and Technology Development Plan [2015ZH078]
- Technology Research Funds Projects of Ocean [2015418022-3]
Chemical modification is one of the prominent methods used to improve the water solubility and bioactivity of chitosan. In this paper, a series of quaternary ammonium chitosan derivatives based on 6-O-chloroacetylated chitosan (CAClC) were successfully designed and synthesized. Detailed structural characterization was carried out by means of FT-IR, H-1 NMR spectroscopy, and elemental analysis. Furthermore, the antifungal activity against Botrytis cinerea, Gibberella zeae, and Physalospora piricola Nose was estimated using in vitro hypha measurements. Most of the quaternary ammonium chitosan derivatives showed an inhibitory index of >90% at 1.0 mg/mL and exhibited enhanced antifungal activity when compared to chitosan. On one hand, the higher density of positive charge contributed to the antifungal action. In addition, the inhibitory activity decreased roughly in the order of TriM [(CH3)(3)] > TriE (CH2CH3)(3)] > TriP [(CH2CH2CH3)(3)] > TriB [(CH2CH2CH2CH3)(3)]; NNTE (CH3)(2)(CH2CH3)] > NNTB [(CH3)(2)(CH2CH2CH2CH3)] > NNTK RCH3)(2)((CH2)(9)CH3)] at 1.0 mg/mL. The antifungal properties of all the quaternary ammonium chitosan derivatives against the targeted fungi decreased upon increasing the alkyl chain length. (C) 2018 Published by Elsevier B.V.
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