期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
卷 65, 期 -, 页码 289-297出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijbiomac.2014.01.054
关键词
Chitosan nanoparticles; Oxaliplatin; Drug release; Intrinsic apoptotic pathway; MCF-7 cells; In vitro
资金
- University Research Fellowship (URF) from Bharathiar University, UGC-MRP
- DST-Nanomission, Department of Science and Technology, Nano-mission division, New Delhi [SR/NM/NS-60/2010]
This study was to investigate smart pH-responsive drug delivery system (DDS) based on chitosan nano-carrier for its potential intelligent controlled release and enhancing chemotherapeutic efficiency of Oxalipaltin. Oxaliplatin was loaded onto chitosan by forming complexes with degradable to construct nano-carrier as a DDS. Oxaliplatin was released from the DDS much more rapidly at pH 4.5 than at pH 7.4, which is a desirable characteristic for tumor-targeted drug delivery. Furthermore, the possible intrinsic apoptotic signaling pathway was explored by Western blot. It was found that expression of Bax, Bik, cytochrome C, caspase-9 and -3 was significantly up-regulated while the Bcl-2 and Survivin were inhibited in breast cancer MCF-7 cells. For instance, nanoparticles inducing apoptosis in caspase-dependent manner indicate that chitosan nanoparticles could act as an efficient DDS importing Oxalipaltin to target cancer cells. These approaches suggest that smart Oxaliplatin delivery strategy is a promising approach to cancer therapy. (c) 2014 Elsevier B.V. All rights reserved.
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